Phytochemicals for Diabetic Complications

Diabetes Mellitus (DM) is a chronic metabolic disorder of impaired metabolism of Carbohydrates fats and proteins, characterized by hyperglycemia resulting from decreased utilization of carbohydrates and excessive glycogenolysis and Gluconeogenesis from amino acids and fatty acids. People with Diabetes mellitus are at higher risks of developing serous diabetic complications such as neuropathy, nephropathy, cataract and heart attacks. Four molecular mechanisms are involved in the development of diabetic complications; increase in the flux of glucose through polyol pathway, increased intracellular formation of advanced glycation end products (AGES), activation of protein kinase C (PKC) and increased flux through the hexosamine pathway. Among these polyol pathway plays a vital role in the development of diabetic complication. In view of the researchers started working on the synthetic compounds for the treatment of diabetic complications. The failure of synthetic compounds because of their low safety and poor pharmacokinetics made look into alternative source from plants / phytochemicals. So in view of these the book gives details about several plants and phytochemicals reported for the treatment of diabetic complications. The book will be valuable for people works as plants/ phytochemicals for treatment of diabetic complications. This book will also useful for the students, Researchers and teachers in the subjects of Pharmacognosy, Botany, Pharmacy, Ayurveda and other Allied Life Sciences.Provides screening methods for Aldose reductase enzyme, AGEs involved in the diabetic complications.Provides a comprehensive information as plants & phytochemicals reported for diabetic complications.It gives an herbal medicine and neutraceuticals used in the treatment of diabetic complications. Contents: 1. Aldose Reductase Inhibitors Phyto Constituents 2. Aldose Reductase Inhibitors from Plant Extracts 3. Plants as Antiglycation Agents: Nutraceuticals for the Management of Diabetic Complications 4. Plants used in the Management of Diabetic Complications 5. Herbal Medicine in Diabetic Foot Complications About the Author: Ciddi Veeresham has 30 years of experience in teaching and research on Pharmacognosy and pharmacy. He is conducting research work as phytochemicals for diabetic complications microbial biotransformation, Development of Analytical methods for API. He supervised 28 Ph.Ds and published 150 research papers in National and International journals including a patent. He has been awarded several awards such as IDMA best research paper award, APCOST Scientist Award and TS Best Teacher Award. Dr. Ciddi Veeresham received funding for his research projects. He has done Post-doctoral research work at Cornell University, Ithaca, NY, USA for a period of 3 years. He has delivered several invited talks in national and internal conferences and acted as research person for QIP (AICTE) programme for pharmacy teachers in Pharmacognosy. He has completed his B.Pharmacy and Ph.D from Kakatiya University, Warangal, and M.Pharmacy from Birla Institute of Technology, Mesra Ranchi, all in Pharmaceutical Sciences. He is member of several professional associations and Editorial Board member of Journals.