Biopharmaceutics & Pharmacokinetics A Practical Manual

Biopharmaceutics is the study of the chemical and physical properties of drugs, their components, and their activities in living organisms. Pharmacokinetics is the study of drug absorption, distribution, metabolism and excretion. This practical manual of Biopharmaceutics and Pharmacokinetics has been written to meet the needs of pharmacy students to perform the experiments smoothly and effectively and there by consolidate their theoretical concept. Though numerous volumes of excellent text books are available on the various aspects of theory, students and faculties often find it difficult to pick the content and do the experiment smoothly. This book fulfils the vacuum for good practical manual on Biopharmaceutics and Pharmacokinetics. Experimental technique describe in this manual are most updated consumes less time to perform and explains the concept in simple and easy to understand. The major objective of this book is to satisfy the requirements of pharmacy students of various Universities. Contents 1. Construction of Calibration curve for Ciprofloxacin hydrochloride 2. Dissolution Test for Ciprofloxacin hydrochloride Conventional Tablet 3. In vitro Bio-equivalency study of Paracetamol Conventional Tablet 4. Role of Surfactant in enhancement of Bioavailability of Diclofenac sodium – In vitro Method 5. In vitro Absorption Study (or) Transport Characteristics of a Drug across the Small Intestinal Mucosa 6. Drug Absorption Study using In situ Rat Gut Technique 7. Effect of pH on Partition Coefficient of Salicylic acid 8. Determination of pH Partition Profile of Diclofenac Sodium and Theoretical Estimation of its Apparent Volume of Distribution 9. Determination of Pharmacokinetic Parameters of Aspirin by Urinary Excretion Method 10. Study on Influence of Urinary pH on Excretion of Salicylate 11. In vivo Bioavailability Study of Riboflavin in Healthy Human Volunteers 12. Study on Elimination of Drug Through Saliva 13. Studies on Protein Binding of Ciprofloxacin hydrochloride 14. Study of Protein Binding of ciprofloxacin hydrochloride by Enhancing the concentration of Egg Albumin 15. Design of Hydraulic Model to Test the relationship between Volume of distribution, Clearance and Elimination Rate Constant 16. Determination of Pharmacokinetic Parameters of the Plasma Time Profile obtained by administering oral dose of a drug 17. Determination of Pharmacokinetic Parameters of the given Plasma Time Profile obtained by administering intravenous bolus dose of a drug 18. Determination of Absorption Rate Constant (Ka) from the given Plasma Time Profile 19. Determination of Serum Drug Concentration at a Specific Time Point after Administration of Oral Dose 20. Determination of Creatinine Clearance from the Given Data 21. Dose Calculation for Renal Impaired Patient About the Author D.DHACHINAMOORTHI M.Pharm, Ph. D is presently working as Professor cum Principal of QIS College of Pharmacy, Vengamukkapalem, Ongole, Andhra Pradesh. He has published more than 26 research and review articles in peer reviewed national and international journals and has presented his research work at various international and national conferences. He is holding a position of Associate editor in International Journal of Research in Pharmaceutical Sciences & editorial board member in International Journal of Pharma World Research since its inception. He is the life member of Indian Pharmaceutical Association (IPA). N.VENKATESWARAMURTHY M.Pharm, has 7 years teaching and 3 years industry experience. Presently he is serving as an Associate professor at J.K.K Nataraja College of pharmacy, Komarapalayam, Tamilnadu. He has published more than 10 research articles and has presented his research work at various international and national conferences. He is the life member of Association of Pharmaceutical Teachers of India (APTI).