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Rational engineering of the methylerythritol 4-phosphate (MEP)

Rational engineering of the methylerythritol 4-phosphate (MEP)

Di Volke, Daniel

Pubblicato da Apprimus Wissenschaftsverlag

English 189 pagine 2018 ISBN 9783863596507
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Terpenoids include high value chemicals such as pharmaceuticals, chemical precursors and fine chemicals. Fruthermore, terpenoids are of interest as environmental-friendly replacement of fossil derivate chemicals. Here, the 2 C methyl D erythritol 4 phosphate (MEP) pathway was analyzed in Escherichia coli through metabolic control analysis for production of the model terpenoid isoprene. Several limiting steps were identified and their implication for an efficient pathway design is discussed.

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